SIGNOR, the SIGnaling Network Open Resource, organizes and stores in a structured format signaling information published in the scientific literature.
The captured information is stored as binary causative relationships between biological entities and can be represented graphically as activity flow.
- Search and pathway browser is limited to three model organisms (i.e., Homo sapiens, Mus musculus and Rattus norvegicus)
- Database is not comprehensive (is not complete) for the few organisms to which it is dedicated (e.g., search of select proteins, even using the UniProt accession as the search term, returns no results); this is likely the result of the level of curation, which is prioritizes by the creators of this resource (expert community-driven curation)
- Useful for examing curated pathways (relevant to model organism signaling physiology); also includes visualizations of well-characterized pathways
Very straightforward, easy-to-use, but limited in its use due to small organismal scope and deficits in completeness of the database
- Licata, L., Lo Surdo, P., Iannuccelli, M., Palma, A., Micarelli, E., Perfetto, L., ... & Cesareni, G. (2020). SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update. Nucleic acids research, 48(D1), D504-D510.