OrthoDB presents a catalog of orthologous protein-coding genes across 64 vertebrates, 57 arthropods, 175 fungi, 14 basal metazoans, and 1115 bacteria. Orthology refers to the last common ancestor of the species under consideration, and thus OrthoDB explicitly delineates orthologs at each radiation along the species phylogeny. The database of orthologs presents available protein descriptors, together with Gene Ontology and InterPro attributes, which serve to provide general descriptive annotations of the orthologous groups, and facilitate comprehensive orthology database querying.
This website gives a lot of informations of proteins families. The distribution of the family in the tree of life is very cool.
This database has uses several methods for clustering/annotation, these make the families of orthologs robusts and trustworthy.
Enter your gene/proteine name or id and get a result. The help section is very detailed.
There are sometimes bugs to get the sequences of a family of orthologs, if it is the case actualise the page or close and reopen.
- Evgenia V Kriventseva, Dmitry Kuznetsov, Fredrik Tegenfeldt, Mosè Manni, Renata Dias, Felipe A Simão, Evgeny M Zdobnov, OrthoDB v10: sampling the diversity of animal, plant, fungal, protist, bacterial and viral genomes for evolutionary and functional annotations of orthologs, NAR, Nov 2018, doi:10.1093/nar/gky1053. PMID:30395283
- Evgeny M Zdobnov, Fredrik Tegenfeldt, Dmitry Kuznetsov, Robert M Waterhouse, Felipe A Simão, Panagiotis Ioannidis, Mathieu Seppey, Alexis Loetscher, Evgenia V Kriventseva, OrthoDB v9. 1: cataloging evolutionary and functional annotations for animal, fungal, plant, archaeal, bacterial and viral orthologs Nucleic acids research 45 (D1), D744-D749, 2016
- Evgenia V Kriventseva, Fredrik Tegenfeldt, Tom J Petty, Robert M Waterhouse, Felipe A Simão, Igor A Pozdnyakov, Panagiotis Ioannidis, Evgeny M Zdobnov, OrthoDB v8: update of the hierarchical catalog of orthologs and the underlying free software Nucleic acids research 43 (D1), D250-D256, 2015
- Robert M Waterhouse, Fredrik Tegenfeldt, Jia Li, Evgeny M Zdobnov, Evgenia V Kriventseva, OrthoDB: a hierarchical catalog of animal, fungal and bacterial orthologs Nucleic acids research 41 (D1), D358-D365, 2012
- Robert M Waterhouse, Evgeny M Zdobnov, Fredrik Tegenfeldt, Jia Li, Evgenia V Kriventseva, OrthoDB: the hierarchical catalog of eukaryotic orthologs in 2011 Nucleic acids research 39 (suppl_1), D283-D288, 2010
- Evgenia V Kriventseva, Nazim Rahman, Octavio Espinosa, Evgeny M Zdobnov, OrthoDB: the hierarchical catalog of eukaryotic orthologs Nucleic acids research 36 (suppl_1), D271-D275, 2007