CellPhoneDB is a publicly available repository of curated receptors, ligands and their interactions. Subunit architecture is included for both ligands and receptors, representing heteromeric complexes accurately. This is crucial, as cell-cell communication relies on multi-subunit protein complexes that go beyond the binary representation used in most databases and studies.
CellPhoneDB integrates existing datasets that pertain to cellular communication and new manually reviewed information. CellPhoneDB utilises information from the following data bases: UniProt, Ensembl, PDB, the IMEx consortium, IUPHAR.
CellPhoneDB can be used to search for a particular ligand/receptor or interrogate your own single-cell transcriptomics data.