ChiPPI is a chimeric protein-protein interactions novel method that uses the domain-domain co-occurrence scores in order to identify preserved interactors of chimeric proteins in cancer.
- The browser used to access the site must support flash in order to view networks
- The networks generated by this tool are dynamic and can be altered by the user to be exported as pictures
- Lots of links to external sites for annotations
The website is easy to use and offers many example datasets to help familiarize the user with the tool. There are many keys available to help the user understand the network.
- Frenkel-Morgenstern, M., Gorohovski, A., Tagore, S., Sekar, V., Vazquez, M., & Valencia, A. (2017). ChiPPI: a novel method for mapping chimeric protein–protein interactions uncovers selection principles of protein fusion events in cancer. Nucleic acids research, 45(12), 7094-7105.
- Gorohovski, A., Tagore, S., Palande, V., Malka, A., Raviv-Shay, D., & Frenkel-Morgenstern, M. (2017). ChiTaRS-3.1—the enhanced chimeric transcripts and RNA-seq database matched with protein–protein interactions. Nucleic Acids Research, 45(D1), D790-D795.