The Orphan Enzymes Project (OEP) is dedicated to connecting modern genome sequencing methods with a century of “orphaned” information about enzymes. The goal of the project is to associate an amino-acid sequence with every known orphan enzyme.
Shearer AG, Altman T, Rhee CD. “Finding sequences for over 270 orphan enzymes.” PLoS ONE 9(5): e97250. doi:10.1371/journal.pone.0097250
Ramkissoon K, Miller JK, Ojha S, Watson DS, Bomar MG, Galande AK, Shearer AG. (2013). “Rapid identification of sequences for orphan enzymes to power accurate protein annotation.” PLoS ONE 8(12): e84508. doi:10.1371/journal.pone.0084508